Start the day with what went right.

A study published in the Journal of Clinical Psychiatry found that one dose of psilocybin, paired with psychological support, rapidly reduced chronic suicidal thoughts in adults with severe depression, and the relief persisted for months [298]. That last part is what makes it unusual.

Two separate pieces tell variations of the same story. Works in Progress profiles multiple myeloma, a cancer that originates in bone marrow and is among the most painful diseases there is: a cure has been found, but it was discovered abroad, and American patients are waiting behind a regulatory system that doesn't...

A large international team led by Harvard Medical School and Princeton University published the first complete connectome of a fruit fly's brain and its equivalent of a spinal cord, every neuron, every synapse, charted [155]. It's the first time any animal's complete nervous system has been mapped end to end.

Scientists announced that the world's mangrove forests, which had been losing ground for decades, have staged a remarkable global recovery [690]. Researchers called it "a global turning point" for one of the most carbon-rich and biodiverse ecosystems on Earth.

An NIH-funded study found that researchers could trigger the restorative cellular processes normally reserved for sleep in specific regions of an awake brain [214]. Sleep doesn't restore the whole brain at once; it does targeted maintenance in particular circuits, clearing waste, repairing connections, restoring...

Just beyond central Vancouver, the Squamish Nation is building Senakw, one of the largest and most unusual housing developments in the world, and making substantial money doing it [451]. The site is on Indigenous land that the city could not develop.

Researchers at the University of Cambridge used a machine learning model to design a new vaccine from scratch, one that targets an entire family of human coronaviruses rather than any single strain [492]. It is the first vaccine designed entirely by AI to enter human clinical trials.